• Cefpodoxime sodium salt packaged and labeled.

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SKU: C096

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Description

Cefpodoxime sodium salt is a third generation cephalosporin β-lactam antibiotic.

TOKU-E offers three forms of cefpodoxime: cefpodoxime proxetil (C015), cefpodoxime sodium salt (C096), and cefpodoxime free acid (C016). All forms are soluble in DMSO (dimethyl sulfoxide).

Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3."

    CAS Number

    82619-04-3

    Molecular Formula

    C15H16N5NaO6S2

    Molecular Weight

    449.44

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

    Storage Conditions

    -20°C, store protected from light.

    Tariff Code

    2941.90.5000

    Spectrum

    Cefpodoxime sodium salt is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.

Applications

    Microbiology Applications

    Cefpodoxime sodium salt is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.032 µg/mL – 1 µg/mL
    • For a complete list of cefpodoxime MIC values, click here.

Specifications

    Form

    Powder

    Appearance

    Brown color crystalline powder

    Source

    Synthetic

    Impurity Profile

    Report single impurity

    Water Content (Karl Fisher)

    Report results

    Assay

    (HPLC) Report results

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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