• Cefpodoxime, Free acid packaged and labeled.

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SKU: C016

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Cefpodoxime free acid is a third-generation cephalosporin β-lactam antibiotic.

TOKU-E offers three forms of cefpodoxime: Cefpodoxime Proxetil (C015), Cefpodoxime Sodium (C096), and Cefpodoxime Free Acid (C016). All forms are soluble in DMSO (dimethyl sulfoxide).

Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3.

    CAS Number


    Molecular Formula


    Molecular Weight

    427.46 g/mol

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

    Storage Conditions

    -20°C, protect from light

    Tariff Code



    Cefpodoxime free acid is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.


    Microbiology Applications

    TOKU-E cefpodoxime was used in a study by Lahiri et al. : Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C B-lactamase enzyme.

    Cefpodoxime free acid is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Klebsiella pneumoniae 8 µg/mL - 64 µg/mL
    • Haemophilus influenzae 0.032 µg/mL – 1 µg/mL
    • For a complete list of cefpodoxime MIC values, click here.





    Brown color powder



    Impurity Profile

    Single Impurity: Not more than 3.0%

    Water Content (Karl Fischer)

    Not more than 5.0%



    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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