• Cefotiam packaged and labeled.

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SKU: C095

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Description

Cefotiam dihydrochloride is a second generation cephalosporin β-lactam antibiotic.

Cefotiam dihydrochloride is freely soluble in water.

    CAS Number

    66309-69-1

    Molecular Formula

    C18H23N9O4S3•2HCl

    Molecular Weight

    598.56

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    2-8°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefotiam is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria. Cefotiam is not effective against Pseudomonas aeruginosa.

Specifications

    Form

    Powder

    Appearance

    White powder

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

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