• Cefminox sodium packaged and labeled.

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SKU: C124

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Description

Cefminox sodium is a second generation cephalosporin antibiotic and is soluble in aqueous solution. TOKU-E offers two forms of cefminox: cefminox (C076) and cefminox sodium (C124).

    CAS Number

    92636-39-0

    Molecular Formula

    C16H20N7NaO7S3

    Molecular Weight

    541.56

    Mechanism of Action

    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefminox sodium, like many cephalosporins, is resistant to β-lactamase activity.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.5000

    Spectrum

    Cefminox sodium is a broad spectrum antibiotic targeting a wide range of gram positive and gram negative microbes including anaerobes.

Applications

    Microbiology Applications

    Because of its potent properties against anaerobes, cefminox sodium can be used in cell media culture to select against Bacteroides, Clostridium, and other susceptible anaerobic bacteria.

Specifications

    Form

    Powder

    Appearance

    White powder

    Source

    Semi-synthetic

    Water Content (Karl Fisher)

    18.0-20.0%

    pH

    4.5-6.0

    Optical Rotation

    +62° to +72°

    Assay

    (On Dried Basis): 90.0-97.0%

    Heavy Metals

    ≤10ppm

    Impurities

    As≤1 ppm

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    Jacobs, Michael R., and et al. "In Vitro Activities of Cefminox against Anaerobic Bacteria Compared with Those of Nine Other Compounds." Antimicrobial Agents and Chemotherapy 42.3 (1998): 495-501. www.ncbi.gov. Web. 27 Aug. 2012.

    "Cefminox Sodium Official Monographs." JPDB (n.d.): 332. Ncbi.gov. Web. 12 Mar. 2013.

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