• Cefadroxil packaged and labeled.

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SKU: C119

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Description

Cefadroxil is a first generation cephalosporin antibiotic similar in structure and spectrum as cefalexin and cephradine.  Cefadroxil exhibits bactericidal activity against a wide spectrum of bacteria.

    CAS Number

    50370-12-2

    Molecular Formula

    C16H17N3O5S

    Molecular Weight

    363.39

    Mechanism of Action

    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.

    Storage Conditions

    -20 °C

    Tariff Code

    2941.90.3000

    Spectrum

    Cefadroxil is a broad spectrum antibiotic and has shown to be effective in treating skin and UTI infections caused byStaphylococcus and Streptococcus species.

Applications

    Microbiology Applications

    Cefadroxil is commonly used in clinical <em>in vitro</em> microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Streptococcus pneumoniae 1 μg/ml - 16 μg/ml
    • Staphylococcus auerus 1 μg/ml - 2 μg/ml
    • For a complete list of cefadroxil MIC values, click here

Specifications

    Appearance

    White or almost white powder

    Water Content (Karl Fischer)

    4.2-6.0%

    pH

    4.0-6.0

    Optical Rotation

    +165° to +178°

    Assay

    (On Dried Basis): 950-1050 µg/mg

References

    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    Buck, R. E., and Et. Al. "Cefadroxil, a New Broad-Spectrum Cephalosporin." Antimicrobial Agents and Chemotherapy 11.2 (1977): 324-30. Ncbi.gov. Web. 11 Oct. 2012.

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