• Caspofungin acetate packaged and labeled.

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SKU: C103

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Description

Caspofungin Acetate is the acetate salt of Caspofungin, a lipopeptide echinocandin antifungal which specifically targets the fungal cell membrane. It is semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis.  As  a β-1,3-D-glucan synthesis antagonist, the compound is used to study the effect of environmental and chemical stress on fungal survival.  Caspofungin is an analog of pneumocandin B0.  Caspofungin Acetate is sparingly soluble in water and slightly soluble in ethanol.

    CAS Number

    179463-17-3

    Molecular Formula

    C52H88N10O15 • 2C2H4O2

    Molecular Weight

    1213.42

    Mechanism of Action

    Caspofungin acts as an inhibitor of β(1,3)-D-Glucan synthase, an enzyme required for cell wall synthesis. Inhibition of this enzyme results in a disruption of the fungal cell wall integrity.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.3000

    Spectrum

    Caspofungin Acetate is effective against yeasts and molds including Candida and Aspergillus spp.

Applications

    Microbiology Applications

    Caspofungin  MIC is ≤ 1 µg/ml for Candida.

    For  additional MIC data on Candida or other fungi, please consult our Antimicrobial Index.

Specifications

    Form

    Powder

    Appearance

    White to off-White powder

    Source

    Semi-synthetic; derived from a fermentation product of the fungus Glarea lozoyensis.

    Water Content (Karl Fischer)

    ≤10.0%

    pH

    5.9-6..7

    Assay

    (As Is): 94.5-102.5%

    Sulfated Ash

    ≤0.5%

    Heavy Metals

    ≤20 ppm

References

    References

    Ghannoum MA and Rice LB (1999) Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.  Clin. Microbiol. Rev. 501:17  PMID 10515900 

    Hao B, Cheng S, Clancy CJ and Nguyen MH (2013)  Caspofungin kills Candida albicans by causing both cellular apoptosis and necrosis. Antimicrob. Agents Chemother. 57(1):326-332  PMID 23114781

    Pacetti SA, Gelone SP (2003)  Caspofungin acetate for treatment of invasive fungal infections. Ann Pharmacother. 37(1):90-98 PMID 12503942

    Stone EA, Fung HB, Kirschenbaum HL (2002) Caspofungin: An echinocandin antifungal agent. Clin. Ther. 24(3):351-377  PMID 11952021

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