• Carfilzomib

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SKU: C149

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Description
Carfilzomib is an anti-cancer tetrapeptide epoxyketone drug and is used for the treatment of multiple myeloma.

    CAS Number

    868540-17-4

    Molecular Formula

    C40H57N5O7

    Molecular Weight

    719.91 g/mol

    Mechanism of Action

    Carfilzomib prevents tumor growth by inhibiting 20S proteasome activity which leads to an accumulation of polyubiquinated proteins, and ultimately, cell cycle arrest or apoptosis.

    Storage Conditions

    2-8°C

Specifications

    Appearance

    White solid

    Loss on Drying

    Not more than 1.0%

    Residue On Ignition

    Not more than 0.5%

References

    References

    Pautasso, Chiara, Sara Bringhen, Chiara Cerrato, Valeria Magarotto, and Antonio Palumbo. "The Mechanism of Action, Pharmacokinetics, and Clinical Efficacy of Carfilzomib for the Treatment of Multiple Myeloma." Expert Opinion on Drug Metabolism & Toxicology 9.10 (2013): 1371-379.

    Kortuem, K. M., and A. K. Stewart. "Carfilzomib." Blood 121.6 (2013): 893-97.

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