SKU: C002

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Description

Candicidin is a fungicidal polyene antifungal agent derived from Streptomyces griseus, named for its high activity against the yeast Candida albicans.

    CAS Number

    1403-17-4

    Molecular Formula

    C59H84N2O18

    Molecular Weight

    1109.30

    Mechanism of Action

    Candicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

    Spectrum

    Candicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans.

Specifications

    Form

    Powder

    Appearance

    Brown or Yellow Powder

    Source

    Streptomyces griseus

    Potency (on a dry basis)

    ≥1800 u/mg

    Loss on Drying

    ≤4.0%

References

    References

    Hammond, SM., and Kliger BN (1976)  Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans." Antimicrob. Agents Chemother. 9(4): 561-568

    Waksman, SA et al. (1965) Candicidin and other polyenic antifungal antibiotics. Bulletin of the World Health Organization 33(2): 219-226

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