SKU: C002

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Description

Candicidin is a fungicidal polyene antifungal agent.

    CAS Number

    1403-17-4

    Molecular Formula

    C59H84N2O18

    Molecular Weight

    1109.30

    Mechanism of Action

    Candicidin alters membrane permeability by binding to ergosterol, a membrane sterol unique to fungi. As a result, an intracellular ion imbalance occurs leading to cell death.

    Storage Conditions

    -20°C

    Tariff Code

    2941.90.1050

    Spectrum

    Candicidin targets primarily fungi responsible for vulvovaginal candidiasis namely Candida albicans.

Specifications

    Form

    Powder

    Appearance

    Brown or Yellow Powder

    Source

    Streptomyces griseus

    Potency (on a dry basis)

    ≥1800 u/mg

    Loss on Drying

    ≤4.0%

References

    References

    Hammond, S. M., and B. N. Kliger. "Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida Albicans." Antimicrobial Agents and Chemotherapy 9.4 (1976): 561-68. www.ncbi.gov. Web. 27 Aug. 2012.

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