• Camptothecin sodium

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SKU: C146

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Description
Camptothecin sodium is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin sodium is isolated from either Camptotheca acuminata, a deciduous tree; or Nothapodytes foetida; a fungus.
 

    CAS Number

    25387-67-1

    Molecular Formula

    C20H17N2NaO5

    Molecular Weight

    388.35

    Mechanism of Action

    Camptothecin sodium inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.

    Storage Conditions

    <30┬░

Applications

    Cancer Applications

    Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.

Specifications

    Appearance

    Light yellow crystalline powder

    Assay

    HPLC: Not less than 95.0%

References

    References

    Venditto, Vincent J. "Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature." American Chemical Society (2010): 307-49. Web.

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