• Camptothecin (Camptotheca acuminata)

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SKU: C070

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Description
Camptothecin is an alkaloid topoisomerase l (topo l) inhibitor with anticancer properties. Camptothecin is isolated from Camptotheca acuminata, a deciduous tree.

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    CAS Number

    7689-03-4

    Molecular Formula

    C20H16N2O4

    Molecular Weight

    348.352

    Mechanism of Action

    Camptothecin inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.

    Storage Conditions

    2-8 ┬░C

Applications

    Cancer Applications

    Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.

Specifications

    Source

    Camptotheca acuminata (plant)

    Impurity Profile

    RRT1.32 Impurity: Not more than 0.7%
    Total Impurities: Not more than 1.0%

    Assay

    Not less than 99.0%

    Loss on Drying

    Not more than 1.0%

    Residue On Ignition

    Not more than 0.3%

References

    References

    Venditto, Vincent J. "Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature." American Chemical Society (2010): 307-49. Web.

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