• Butyrolactone I packaged and labeled in glass vial.

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SKU: B057

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Description
Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

Butyrolactone I is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    87414-49-1

    Molecular Formula

    C24H24O7

    Molecular Weight

    424.5

    Mechanism of Action

    Butyrolactone I inhibits the cell cycle at the G1/S and G2/M transitions.

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    Light yellow solid

References

    References

    Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al. Chem. Pharm. Bull. 1983, 31, 1528.

    Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Suzuki M. et al. Cancer Lett. 1999, 138, 121.

    Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Kitagawa M. et al. Oncogene 1993, 8, 2425.

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