• Bromamphenicol packaged and labeled in glass vial.

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SKU: B055

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Description
Bromamphenicol is a semi-synthetic chloramphenicol analogue first reported in 1950, in which the dichloroacetamide is replaced with dibromoacetamide. Bromamphenicol possesses weak antibiotic activity. Comparative crystallography with chloramphenicol helped defined the SARs of the acetamide binding region on the ribosome. More recently, this relationship was used to demonstrate that chloramphenicol binding to DraE virulence factors in Gram negative bacteria was independent of chloramphenicol binding site on the ribosome.

Bromamphenicol is soluble in ethanol, methanol, DMF and DMSO.

    CAS Number

    16803-75-1

    Molecular Formula

    C11H12Br2N2O5

    Molecular Weight

    412.0

    Storage Conditions

    -20┬░C

Specifications

    Appearance

    White solid

References

    References

    X-Ray analysis of some antibiotic substances. Dunitz J.D. & Leonard J.E. J. Am. Chem. Soc. 1950, 72, 4276.

    The crystal structure of chloramphenicol and bromamphenicol. Dunitz J.D. J. Am. Chem. Soc. 1952, 74, 995.

    A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol. Pettigrew D.M. et al. Acta Cryst. Set. D 2009, 65, 513.

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