• Berninamycin A, EvoPure� packaged and labeled in glass vial.

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SKU: B046

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Description
Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic 'peptide' comprising atypical amino acids linked to thiazole and oxazoles. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Berninamycin A is soluble in DMF and DMSO. 

    CAS Number

    58798-97-3

    Molecular Formula

    C51H51N15O15S

    Molecular Weight

    1146.1

    Mechanism of Action

    Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central to multidrug resistance.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Berninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al. , J.Am.Chem.Soc. 1976, 98, 299. 

    Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303. 

    Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et al. , Cancer Res. 2006, 19, 9731.

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