• Bafilomycin A1, EvoPure� packaged and labeled in glass vial.

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SKU: B038

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Description
Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumor cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Bafilomycin A1 is soluble in ethanol, methanol, DMF and DMSO. NOTE: forms methyl ketal on long term storage in methanol.

    CAS Number

    88899-55-2

    Molecular Formula

    C35H58O9

    Molecular Weight

    622.8

    Mechanism of Action

    Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Bowman E.J. et al. Proc Natl Acad Sci USA. 1988, 85, 7972. 

    Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. Yoshimori T. et al. J Biol Chem. 1991, 266, 17707. 

    Vacuolar ATPase as a drug discovery target. Niikura K. Drug News Perspect. 2006, 19, 139.

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