• Azamulin packaged and labeled in glass vial.

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SKU: A140

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Description
Azamulin is a semi-synthetic pleuromutilin prepared by sequential reaction of dihydropleuromutilin tosylate with 2-amino-1,2,4-triazole-5-thiol. While azamulin is a broad spectrum antibiotic in the pleuromutilin class, this aspect of its bioprofile has received little attention. In fact, the triazole substituent added to nominally improve the drug's bioavailability, imparted an unusual selectivity for the inhibition of specific cytochrome P450 mixed function oxidase sub-types, important for understanding the manner in which the body metabolises drugs or xenobiotics.

Azamulin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.

    CAS Number

    76530-44-4

    Molecular Formula

    C24H36N4O4S

    Molecular Weight

    476.6

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    A comparative study of 1-substituted imidazole and 1,2,4-triazole antifungal compounds as inhibitors of testosterone hydroxylations catalysed by mouse hepatic musomal cytochromes P-450 Ballard, S. et al. Biochem. Pharmacol. 1988, 37, 4643.

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