• Avibactam sodium

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SKU: A156

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Description

Avibactam sodium is a β-lactamase inhibitor without a β-lactam core that can inhibit class A and C enzymes, along with some class D enzymes. It is effective against Enterobacteriaceae.  Avibactam sodium can be used for strain manipulation and drug resistance studies.  

    CAS Number

    1192491-61-4

    Molecular Formula

    C7H11N3NaO6S

    Molecular Weight

    287.23

    Mechanism of Action

    Avibactam is a nucleophilic serine enzyme inhibitor that contains a diazabicyclooctane (DBO) core, unlike the other β -lactamases, or PBPs (penicillin-binding protein) inhibitors, that contain a β -lactam ring.

    Storage Conditions

    -20°C

Applications

    Eukaryotic Cell Culture Applications

    Avibactam can restore the antimicrobial properties of partner cephalosporins in vitro against Enterobacteriaceae (Lagacé-Wiens et al, 2011).

    Microbiology Applications

    Avibactam is effective against Enterobacteriaceae.

Specifications

    Form

    White to off-white powder

References

    References

    Abboud I et al (2016) Interaction of avibactam with class B metallo-B-lactamases. Antimicrob. Agents Chemother. 60(10):5655-5662 27401561

    Ehmann DE (2012) Avibactam is a covalent, reversible, non-B-lactam B-lactamase inhibitor. PNAS 109(29):11663-1166822753474

    Lagacé-Wiens PS et al (2011) Activity of NXL104 in combination with β-lactams against genetically characterized Escherichia coliand Klebsiella pneumoniae isolates producing Class A extended-spectrum β-lactamases and class C beta-lactamases. Antimicrob. Agents Chemother. 55 (5):2434-2437 21357295

    Lahiri SD et al (2015) Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC. J. Antimicrob. Chemother 70(6):1650-1658 PMD 25645206

    Lahiri, S., Olivier, N., Alm, R., Johnstone, M., & McLaughlin, R. (2014). Avibactam and class C beta-lactamases: Mechanism of inhibition, conservation of binding pocket and implications for resistance. Antimicrob. Agents Chermother. 58(10), 5704-5713.

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