• Avermectin B1b

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SKU: A139

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Description
Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains an isopropyl residue in the 25-position. In vitro and in vivo studies have shown this analogue to be active, but less potent than the B1a analogue.

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    CAS Number

    65195-56-4

    Molecular Formula

    C47H70O14

    Molecular Weight

    859.1

    Storage Conditions

    -20°C

Specifications

    Appearance

    White solid

References

    References

    Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al. et al. Proc Natl Acad Sci U S A. 1979, 76, 2062.

    Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans.Cully D.F. et al. Mol Pharmacol. 1991, 40, 326.

    Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.Wolstenholme A.J. and Rogers A.T. Parasitology. 2005, 131, S85-95 (Review).

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