SKU: A150

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Description
Aureusimine B (phevalin) is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valine. Aureusimine B was isolated from S. aureus in 2010 as one of a pair of related metabolites, controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B is also an inhibitor of the protease, calpain.

Aureusimine B is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility

    CAS Number

    170713-71-0

    Molecular Formula

    C14H16N2O

    Molecular Weight

    228.3

References

    References

    Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Wyatt M.A. et al. Science 2010, 329, 294

    Aureusimines in Staphylococcus aureus are not involved in virulence. Sun F. et al. PLoS 2010, 5, e15103.

    Phevalin, a new calpain inhibitor, from a Streptomyces sp. Alvarez M.E. et al. J. Antibiot. 1995, 48, 1165.

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