• Asunaprevir

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SKU: A108

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Description
Asunaprevir is a tripeptidic acylsulfonamide antiviral compound and is currently being used as an experimental drug fro the treatment of hepatitis C.

    CAS Number

    630420-16-5

    Molecular Formula

    C35H46ClN5O9S

    Molecular Weight

    748.29

    Mechanism of Action

    Asunaprevir targets and inhibits the NS3 protease enzyme which is essential for HCV replication.

    Storage Conditions

    -20°C

Specifications

    Form

    Powder

    Appearance

    White to yellow powder

    Impurity Profile

    Related substances:
    Any impurity: Not more than 0.3%
    Total impurities: Not more than 1.0%

    Water Content (Karl Fisher)

    Not more than 1.0%

    Assay

    98.0% - 102.0%

    Residue On Ignition

    Not more than 0.1%

    Heavy Metals

    Not more than 20ppm

    Residual Solvents

    Tetrahydrofuran: Not more than 0.072%
    Ethanol: Not more than 0.5%
    Ethyl Acetate: Not more than 0.5%

References

    References

    Gentile, Ivan, Antonio Riccardo Buonomo, Emanuela Zappulo, Giuseppina Minei, Filomena Morisco, Francesco Borrelli, Nicola Coppola, and Guglielmo Borgia. "Asunaprevir, a Protease Inhibitor for the Treatment of Hepatitis C Infection." Therapeutics and Clinical Risk Management TCRM (2014): 493.

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