• Apoptolidin packaged and labeled in glass vial.

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SKU: A130

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Description
Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines.

Apoptolidin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility. 

    CAS Number

    194874-06-1

    Molecular Formula

    C58H96O21

    Molecular Weight

    1129.4

    Mechanism of Action

    The apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition; however, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White Lyophilisate

References

    References

    Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Wender P.A. et al. Org. Lett. 2006, 8, 589.

    Apoptolidin: induction of apoptosis by a natural product. Daniel P.T. et al. Angew. Chem. Int. Ed. Engl. 2006, 45, 872.

    Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Salomon A.R. et al. Proc. Natl Acad. Sci. USA 2000, 97, 14766.

    Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. Kim J.W. et al. J. Antibiot. 1997, 50, 628.

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