• Antimony potassium tartrate trihydrate

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Description
Antimony potassium tartrate trihydrate (emetic tarter, potassium antimonyl tartrate, or potassium antimontarterate) is a unique compound used as an emetic and for the treatment of the parasitic infections, schistosomiasis and leishmaniasis. Recently, antimony potassium tartrate trihydrate has been found to have antiangiogenic and antitumor properties in nonsmall-cell lung cancer (NSCLC) cells.

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    CAS Number

    28300-74-5

    Molecular Formula

    K2Sb2(C4H2O6)2 · 3 H2O

    Molecular Weight

    667.87

    Mechanism of Action

    The mode of action of antimony potassium tartrate is not well understood. It is thought that antimony anti-parasitic activity arises from a process of apoptosis involving externalization of phosphatidylserine and DNA fragmentation.

    Storage Conditions

    ≤30°C

References

    References

    Sereno, D., M. Cavaleyra, K. Zemzoumi, S. Maquaire, A. Ouaissi, and J. L. Lemesre. "Axenically Grown Amastigotes of Leishmania Infantum Used as an In Vitro Model To Investigate the Pentavalent Antimony Mode of Action." Antimicrobial Agents and Chemotherapy 42.12 (1998): 3097-102.

    Wang, B., W. Yu, J. Guo, X. Jiang, W. Lu, M. Liu, and X. Pang. "The Antiparasitic Drug, Potassium Antimony Tartrate, Inhibits Tumor Angiogenesis and Tumor Growth in Nonsmall-Cell Lung Cancer."Journal of Pharmacology and Experimental Therapeutics 352.1 (2014): 129-38.

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