• Amphotericin B, solubilized packaged and labeled in glass bottle.

click on thumbnail to zoom
SKU: A008

  Click 'Bulk Order' for 10 or more
Price: make selection(s)

Amphotericin B, Solublized is a solubilized form of the polyene antifungal or antimycotic, amphotericin B.

Amphotericin B is derived from Streptomyces nodosus and is nearly insoluble in water in its standard powder form. The addition of sodium deoxycholate is required in order to maximize the solubility.

    CAS Number

    1397-89-3 (Amphotericin B)

    Molecular Formula

    C47H73NO17 (Amphotericin B)

    Molecular Weight

    924.08 (Amphotericin B)

    Mechanism of Action

    Amphotericin B associates with membrane sterols in mammalian and fungal cell membranes. Amphotericin B forms a pore in these membranes leading to essential ion leakage and ultimately, cell death.

    Storage Conditions


    Tariff Code



    Amphotericin B is active against mammalian and fungal (molds and yeasts) cells. Amphotericin B is not toxic to bacteria due to their lack of sterols.

    The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

    • Candida albicans - 0.001 - 321 μg/mL
    • Candida krusei - 0.001 - 16 μg/mL
    • Coccidioides immitis - 0.0625 - 2 μg/mL
    • Cryptococcus neoformans - 0.2 - 39 μg/mL
    • Fusarium oxysporum - 0.75 - 125 μg/mL


    Eukaryotic Cell Culture Applications

    Amphotericin B can be used in eukaryotic cell culture to control or prevent fungal contamination. Amphotericin B can be toxic to cell lines at high concentrations and should not be used at concentrations greater than 2.50 µg/mL.

    Microbiology Applications

    Amphotericin B is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.





    Yellow or orange powder


    Streptomyces nodosus


    (As Is): ≥240 µg/mg


    Mycoplasma: None detected


    ≤40 EU/mg



    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Brajtburg, J., W. G. Powderly, and G. Medoff. "Amphotericin B: Current Understanding of Mechanisms of Action." Antimicrobial Agents and Chemotherapy 34.2 (1990): 183-88. www.ncbi.gov. Web. 22 Aug. 2012.

    Perez-de-Luque A., Cifuentes Z., Beckstead J.A., Sillero J.C., Avila C., Rubio J. and Ryan R.O.. Effect of amphotericin B nanodisks on plant fungal diseases. Volume 68, Issue 1, Article first published online: 24 Jun 2011.

Other Items In This Category