• Amphotericin B, solubilized packaged and labeled in glass bottle.

click on thumbnail to zoom
SKU: A008

  Click 'Bulk Order' for 10 or more
Price: make selection(s)

Amphotericin B, solublized is a solubilized form of the polyene antifungal or antimycotic, amphotericin B. Amphotericin B is a polyene antifungal or antimycotic compound derived from Streptomyces nodosus.

Standard powder amphotericin B is nearly insoluble in water and requires the addition of sodium deoxycholate to maximize solubility.

    CAS Number

    1397-89-3 (Amphotericin B)

    Molecular Formula

    C47H73NO17 (Amphotericin B)

    Molecular Weight

    924.08 (Amphotericin B)

    Mechanism of Action

    Amphotericin B associates with membrane sterols in mammalian and fungal cell membranes. Amphotericin B forms a pore in these membranes leading to essential ion leakage and ultimately, cell death.

    Storage Conditions


    Tariff Code



    Amphotericin B is active against mammalian and fungal (molds and yeasts) cells. Amphotericin B is not toxic to bacteria due to their lack of sterols.

    The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

    • Candida albicans - 0.001 - 321 μg/mL
    • Candida krusei - 0.001 - 16 μg/mL
    • Coccidioides immitis - 0.0625 - 2 μg/mL
    • Cryptococcus neoformans - 0.2 - 39 μg/mL
    • Fusarium oxysporum - 0.75 - 125 μg/mL


    Eukaryotic Cell Culture Applications

    Amphotericin B can be used in eukaryotic cell culture to control or prevent fungal contamination. Amphotericin B can be toxic to cell lines at high concentrations and should not be used at concentrations greater than 2.50 µg/mL.

    Microbiology Applications

    Amphotericin B is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.





    Yellow or orange powder


    Streptomyces nodosus


    (As Is): ≥240 µg/mg


    Mycoplasma: None detected


    ≤40 EU/mg



    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

    Brajtburg, J., W. G. Powderly, and G. Medoff. "Amphotericin B: Current Understanding of Mechanisms of Action." Antimicrobial Agents and Chemotherapy 34.2 (1990): 183-88. www.ncbi.gov. Web. 22 Aug. 2012.

    Perez-de-Luque A., Cifuentes Z., Beckstead J.A., Sillero J.C., Avila C., Rubio J. and Ryan R.O.. Effect of amphotericin B nanodisks on plant fungal diseases. Volume 68, Issue 1, Article first published online: 24 Jun 2011.

Other Items In This Category