• 5-Fluorocytosine packaged and labeled.

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SKU: F003

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Description

5-fluorocytosine is a sparingly soluble (10.5 mg/mL) fluorinated cytosine (pyrimidine) analog.

    CAS Number

    2022-85-7

    Molecular Formula

    C4H4FN3O

    Molecular Weight

    129.09

    Mechanism of Action

    5-fluorocytosine is taken up by the fungus and is converted to 5-fluorouracil. During transcription, the pyrimidine analog is incorporated into the RNA which inhibits subsequent rounds of transcription.

    Storage Conditions

    2-8°C, store protected from light.

    Tariff Code

    2933.59.3600

    Spectrum

    5-fluorocytosine targets primarily Candida and Cyptococcus species.

Specifications

    Form

    Powder

    Appearance

    White or almost white crystalline powder

    Source

    Synthetic

    Assay

    98.5-101.0% (on dried basis)

    Loss on Drying

    ≤1.5%

    Residue On Ignition

    ≤0.1%

    Heavy Metals

    ≤0.002%

References

    References

    Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

    Waldorf, A. R., and A. Polak. "Mechanisms of Action of 5-fluorocytosine." Antimicrobial Agents and Chemotherapy 23.1 (1983): 79-85. www.ncbi.gov. Jan. 1983. Web. 22 Aug. 2012.

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