• 5-Azacytidine

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SKU: A095

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Description
5-azacytidine is a nucleoside analog of cytidine and is used to treat myelodysplasic syndrome (MDS).

    CAS Number

    320-67-2

    Molecular Formula

    C8H12N4O5

    Molecular Weight

    244.205

    Mechanism of Action

    The mechanism of action of 5-azacytidine is currently debated; however, two likely mechanisms have been proposed. Because of its similarity to cytidine, 5-azacytidine is believed to be incorporated into DNA and RNA of bone marrow at high doses. At lower doses, 5-azacytidine is thought to inhibit DNA methyltransferase activity leading to a decrease in DNA methylation.

    Storage Conditions

    -20°C

Specifications

    Appearance

    White or off-white solid

    Loss on Drying

    Not more than 1.0%

References

    References

    Christman, Judith K. "5-Azacytidine and 5-aza-2′-deoxycytidine as Inhibitors of DNA Methylation: Mechanistic Studies and Their Implications for Cancer Therapy." Oncogene 21.35 (2002): 5483-495. Web.

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