• 4-epi-oxytetracycline, EvoPure packaged and labeled.

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SKU: O008

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Description

4-epi-oxytetracycline (oxytetracycline related compound A) is an oxytetracycline metabolite often formed in weak acid environments and high temperatures. Other oxytetracycline metabolites include α-apo-oxytetracycline (oxytetracycline related compound D) and β-apo-oxytetracycline (oxytetracycline related compound E). 4-epi-oxytetracycline is soluble in water (0.5 mg/mL), methanol, and DMSO.

    CAS Number

    14206-58-7

    Molecular Formula

    C22H24N2O9

    Molecular Weight

    460.43

    Mechanism of Action

    Like oxytetracycline, in acellular systems of synthesis of polyphenylalanine with ribosomes from tetracycline sensitive and resistant strains of E. coli, minocycline and oxytetracycline had close inhibiting activity. 4-Epi-oxytetracycline and beta-apo-oxytetracycline possessing competing properties with respect to oxytetracycline at the stage of penetration through the cell membrane did not, however, suppress the synthesis of polyphenylalanine in the acellular system isolated from the sensitive strain of E. coli.

    Storage Conditions

    -20 °C

    Tariff Code

    2941.30.0000

    Spectrum

    About 5% of the potency against Staphylococcus aureus when compared with oxytetracycline

Applications

    Application

    4-epi-oxytetracycline can be used as a secondary reference standard.

    Microbiology Applications

    4-epi-oxytetracycline has only 5% of the potency against Staphylococcus aureus and E. coli in comparing with oxytetracycline. 4-epi-oxytetracycline can also be used to prepare S. aureus and E. coli selective media.

Specifications

    Form

    Powder

    Source

    Synthetic

Technical Data

HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].

References

    References

    Richeng, Xuan, et. al.. "Hydrolysis and Photolysis of Oxytetracycline in Aqueous Solution." Journal of Environmental Science and Health 45 (2010): 73-81. Usda.gov. Web. 10 Apr. 2013.

    Beliavskaia IV et al. "Study of the mechanism of action of minocycline and of certain other tetracycline group compounds". Antibiotiki, 1976 Mar, 21(3), 242 - 5.

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