• 1,10-Phenanthroline hydrochloride monohydrate

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SKU: P067

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Description
1,10-phenanthroline hydrochloride monohydrate is a herterocyclic compound with antimycotic and anticancer properties.

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    CAS Number

    18851-33-7

    Molecular Formula

    C12H8N2 · HCl · H2O

    Molecular Weight

    234.68

    Mechanism of Action

    1,10-phenanthroline HCl monohydrate damages mitochondrial function in fungi by disabling the ability to reduce 2,3,5-triphenyltetrazolium chloride (TTC). 1,10-phenanthroline also inhibits DNA synthesis in cancer cells; however, the mechanism is poorly understood.

Specifications

    Appearance

    White to off-white powder

    Water Content (Karl Fisher)

    Not more than 8.5%

References

    References

    Deegan, Carol. "In Vitro Cancer Chemotherapeutic Activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] · 2H2O, [Cu(phen)2(mal)] · 2H2O and [Mn(phen)2(mal)] · 2H2O (malH2 = Malonic Acid) Using Human Cancer Cells." Cancer Letters 247.2 (2007): 224-33. Web.

    Coyle, Barry. "Mode of Anti-fungal Activity of 1,10-phenanthroline and Its Cu(II), Mn(II) and Ag(I) Complexes." BioMetals 16 (2003): 321-29. Web.

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