• α-apo-oxytetracycline, EvoPure packaged and labeled.

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SKU: O009

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Description

α-Apo-oxytetracycline, EvoPure® (oxytetracycline-related compound D) is an oxytetracycline metabolite and impurity found in commercial oxytetracycline.  It is formed via acid hydrolysis of oxytetracycline.  It is an isomer of β-Apo-oxytetracycline that forms readily in acidic and basic media.  It can be used as a QC standard during stability studies of oxytetracycline and can be used to study the degradation pathway and products of tetracyclines.  α -Apo-oxytetracycline, EvoPure® is very slightly soluble in water.

 We also offer:

  • 4-Epi-oxytetracycline, EvoPure® (oxytetracycline-related compound A)(O008)
  • β -Apo-oxytetracycline, EvoPure® (oxytetracycline-related compound E)(O010)

    CAS Number

    18695-01-7

    Molecular Formula

    C22H22N2O8

    Molecular Weight

    442.42

    Mechanism of Action

    Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.

    Storage Conditions

    -20°C

    Tariff Code

    2941.30.0000

    Spectrum

    broad-spectrum, including Gram-negative and Gram-positive bacteria.

Applications

    Application

    α-Apo-oxytetracycline is commonly used as a secondary standard.

Specifications

    Source

    semi-synthetic

Technical Data

HPLC, NMR, FTIR, and MS analysis may be available. For more info, please email [email protected].

References

    References

    Halling-Sorensen B, Sengelov G and Tjornelund J (2002)  Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline-resistant bacteria. Arch. Environ. Contam. Toxicol. (2002) 42(3): 263-271  PMID  11910453

    Richeng X et al (2010) Hydrolysis and photolysis of Oxytetracycline in aqueous solution. J. Environ. Sci. and Health 45:73-81 PMID 20390934

    Lykkeberg AK, Halling-Sørensen B, Cornett C, Tjørnelund J and Honoré HS (2004)   Quantitative analysis of Oxytetracycline and its impurities by LC-MS-MS. J. Pharm. Biomed. Anal. 34(2):325-332  PMID 15013146

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