Gentamicin C2a sulfate is one of three components of the gentamicin C complex and can comprise 25-55% gentamicin depending on the manufacturer or manufacturing process. The gentamicin C complex comprises approximately 80% gentamicin and exhibits the most potent antimicrobial activity. The higher antimicrobial activity of the group C gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments. Gentamicin C2 and C2a are both stereoisomers. Gentamicin C2a EvoPure® is ≥95.0% gentamicin C2a.
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Mechanism of Action
Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.
Gentamicin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.
Gentamicin EvoPure® compounds can be used to study effects of individual gentamicin components on various bacterial strains.
Representative MIC values include:
- Bacillis subtilis ATCC 6633: 0.02 µg/mL
- Escherichia coli ATCC 10536: 2.2µg/mL
- Staphylococcus aureus ATCC 6538P 1.0 µg/mL
Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.
Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)
Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.Weinstein, Marvin J. "Biological Activity of the Antibiotic Components of the Gentamicin Complex." Journal of Bacteriology 94.3 (1967): 789-90. Web. 15 Oct. 2013.
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