Gentamicin C2a sulfate, EvoPure packaged and labeled.

530.00530.00
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G03410 mg
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  • Description

    Gentamicin C2a sulfate is one of three components of the gentamicin C complex and can comprise 25-55% gentamicin depending on the manufacturer or manufacturing process. The gentamicin C complex comprises approximately 80% gentamicin and exhibits the most potent antimicrobial activity. The higher antimicrobial activity of the group C gentamicins is thought to arise from the lack of hydroxy groups on the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) fragments. Gentamicin C2 and C2a are both stereoisomers. Gentamicin C2a EvoPure® is ≥95.0% gentamicin C2a.

    For more gentamicin products, click here.

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Spectrum

    Gentamicin is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

    • Microbiology Applications

      Gentamicin EvoPure® compounds can be used to study effects of individual gentamicin components on various bacterial strains.

        Representative MIC values include:

      • Bacillis subtilis ATCC 6633: 0.02 µg/mL
      • Escherichia coli ATCC 10536: 2.2µg/mL
      • Staphylococcus aureus ATCC 6538P 1.0 µg/mL

    • References

      Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

      Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)

      Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.

      Weinstein, Marvin J. "Biological Activity of the Antibiotic Components of the Gentamicin Complex." Journal of Bacteriology 94.3 (1967): 789-90. Web. 15 Oct. 2013.

    Form

    Powder

    Purity Level

    ≥95.0%

    Tariff Code

    2941.90.1010

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number59751-72-3
    Molecular Formula

    C20H41N5O· xH2SO4 (lot specific)

    Molecular Weight463.57 g/mol (Free base)
    FormPowder
    AppearanceWhite or off-white powder
    Purity Level≥95.0%
    SolubilitySoluble
    SourceMicromonospora spp.
    pH3.5-5.5
    Storage Conditions-20°C
  • Spectral Data - Gentamicin C2a sulfate, EvoPure®


    HNMR Spectra


          

    Click to enlarge

    Solvent: D2O
    Instrument: Mercury 300
    Frequency: 300 MHz

     

    FTIR Spectra

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    Mass Spectra

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    Polarity/Scan Type: Positive
    Solvent: H2O
    Solution Concentration: 10 mg/mL