Gentamicin A sulfate, EvoPure packaged and labeled.

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G03510 mg
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  • Description

    Gentamicin A is one of several different components found in standard grade gentamicin. Gentamicin A, gentamicin B, gentamicin X2, and others are considered “minor components,” have little antimicrobial activity, and account for approximately 20% of standard grade gentamicin. The major components of gentamicin are members of the gentamicin C complex which account for up to 80% of standard grade gentamicin and possess higher antimicrobial properties. The minor gentamicin components (A, B, X2, etc..) contain hydroxy groups in the 3’ and 4’ positions of the purpurosamine (2-amino-hexose) ring. The gentamicin C complex does not have hydroxy groups at these locations. This structural difference is thought to account for the difference in antimicrobial activity between the minor (gentamicins A, B, X2, etc..) and the gentamicin C complex. Gentamicin A sulfate, EvoPure® is ≥99.0% gentamicin A.

    For more gentamicin products, click here.

    Huang et al. used gentamicin A sulfate, EvoPure® and gentamicin X2 sulfate, EvoPure® to study enzymatic conversion of gentamicin A2 to other gentamicin congeners. "Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex."

    Mechanism of Action

    Aminoglycosides target the 30S ribosomal subunit resulting in an inability to read mRNA ultimately producing a faulty or nonexistent protein.

    Spectrum

    Gentamicin is a broad spectrum antibiotic targeting a wide range of Gram positive and Gram negative bacteria. Interestingly, gentamicin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."

    • Microbiology Applications

      Gentamicin EvoPure® compounds can be used to study effects of individual gentamicin components on various bacterial strains.

    • References

      Davis, Bernard D. "Mechanism of Bactericidal Action of Aminoglycosides."Microbiological Reviews 51.3 (1987): 341-50.

      Sarna, Katarzyna, and Agata Blazewicz. "Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection." PubMed (2010)

      Vydrin, A. F. "Component Composition of Gentamicin Sulfate Preparations." Pharmaceutical Chemistry Journal 37.8 (2003): 448-49. Web. 15 Oct. 2013.

    Form

    Powder

    Purity Level

    ≥99.0%

    Tariff Code

    2941.90.1010

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number13291-74-2
    Molecular FormulaC18H36N4O10 · xH2SO4 (lot specific)
    Molecular Weight468.50 g/mol (Free base)
    FormPowder
    AppearanceWhite powder
    Purity Level≥99.0%
    SourceMicromonospora spp.
    Storage Conditions-20°C
  • Spectral Data - Gentamicin A, EvoPure®


    HNMR Spectra


          

    Click to enlarge

    Solvent: cdc13
    Instrument: Mercury 300
    Frequency: 300 MHz

     

    FTIR Spectra

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    Mass Spectra

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    Polarity/Scan Type: Positive
    Solvent: H2O
    Solution Concentration: 10 mg/mL