Colistin sodium methanesulfonate packaged and labeled.

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  • Description

    Colistin is a unique sparingly soluble cyclic polypeptide antibiotic known as a polymyxin. Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability. New Delhi metallo-β-lactamase multidrug-resistant Enterobacteriaceae have also shown susceptibility to Colistin.

    TOKU-E offers two forms of colistin: colistin sulfate (C083) and colistin sodium methanesulfonate (C073) (also known as colistimethate sodium). Both forms of colistin are freely soluble in aqueous solution.  Colistin sodium methanesulfonate (CMS) is considered an inactive prodrug which means it is inactive until converted into colistin by cellular enzymes.  Colistin sulfate (colistin) however, is the end product of CMS and does not require molecular conversion for antimicrobial properties.

    Mechanism of Action

    Colistin has a bactericidal effect on bacteria by targeting the cell membrane and modifying its permeability.

    Spectrum

    Colistin primarily targets and disrupts the cell wall of gram negative bacteria.

    • Microbiology Applications

      Colistin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

      • Shigella spp. 64 µg/mL -128 µg/mL
      • Haemophilus influenzae 0.4 µg/mL – 0.8 µg/mL
      • For a complete list of colistin MIC values, click here.

    • References

      Falagas, M. E. "Colistin: The Revival of Polymyxins for the Management of Multidrug-resistant Gram-negative Bacterial Infections." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 40.9 (2005): 1333-341. www.ncbi.gov. Web. 10 Sept. 2012.

      Bergen, Philip J. et. al. "Colistin Methanesulfonate Is an Inactive Prodrug of Colistin against Pseudomonas Aeruginosa." Antimicrobial Agents and Chemotherapy 50.6 (2006): 1953-958. Ncbi.gov. Web. 5 Oct. 2012.

    Form

    Powder

    Tariff Code

    2941.90.1050

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number8068-28-8
    Molecular FormulaC58H115N16Na5O28S5
    Molecular Weight1759.90
    FormPowder
    AppearanceA white to slightly yellow fine powder
    SourceBacillus polymyxa
    pH6.5-8.5
    Optical Rotation-46° to -51°
    Storage Conditions2-8 °C
    Assay≥390 µg/mg
    Loss on Drying≤5.0%
    Sulfated Ash16-21%
    Heavy Metals≤20 ppm
    Identification
    Endotoxin≤390 µg/mg