Chloramphenicol packaged and labeled.

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  • Description

    Chloramphenicol is a bacteriostatic antibiotic that inhibits bacterial protein synthesis.

    Mechanism of Action

    After entering a bacterial cell, chloramphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.


    Chloramphenicol is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria especially those which cause meningitis.

    • Microbiology Applications

      Chloramphenicol is routinely used to select for transformed cells that express the chloramphenicol resistance gene, cat from a resistance plasmid at concentrations between 25 - 35 µg/mL.

      Media Supplement

      Chloramphenicol is used as a selective agent in Dermasel agar, a growth media designed for selection of dermatophyte fungi from hair, nails, and skin scrapings.

      ChromogenicCandida Agar - Candida Selective Supplement

    • Plant Biology Applications

      Because chloroplasts are derived from Cyanobacteria, plants are susceptible to the effects of chloramphenicol. Chloramphenicol can therefore be used as a gene selection agent for resistant plants containing the cat gene.

    • References

      Sharma K.K., Bhatnagar-Mathur P. and Thorpe T.A. Genetic transformation technology: status and problems. In Vitro Cell. Dev. Biol.—Plant 41:102–112, March–April 2005

      Li W., Ruf S. and Bock R., Chloramphenicol acetyltransferase as selectable marker for plastid transformation. Plant Mol Biol (2011) 76:443–451

      Mayer, Gene, Dr. "Antibiotics - Protein Synthesis, Nucleic Acid Synthesis, and Metabolism." University of South Carolina School of Medicine. Web. 21 Aug. 2012.



    Purity Level


    Tariff Code


    Related Documents

    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to

  • CAS Number56-75-7
    Molecular FormulaC11H12Cl2N2O5
    Molecular Weight323.13 g/mol
    AppearanceWhite to greyish-white or yellowish-white, needle-like crystals or elongated plate
    Purity Level97.0%-103.0%
    SourceStreptomyces venezuela
    pH4.5 - 7.5
    Melting Point149°C - 153°C
    Optical Rotation+17.0º to +20.0º
    Storage Conditions2-8 °C. Store protected from light