Chloramphenicol packaged and labeled.

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  • Description

    Chloramphenicol is a bacteriostatic antibiotic that inhibits bacterial protein synthesis.

    Mechanism of Action

    After entering a bacterial cell, chloramphenicol binds to the 50S ribosomal subunit preventing peptide bond formation. Resistance to chloramphenicol may be due to decreased cell permeability or a mutation in the 50S ribosomal subunit.

    Spectrum

    Chloramphenicol is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria especially those which cause meningitis.

    • Microbiology Applications

      Chloramphenicol is routinely used to select for transformed cells that express the chloramphenicol resistance gene, cat from a resistance plasmid at concentrations between 25 - 35 µg/mL.

      Media Supplement

      Chloramphenicol is used as a selective agent in Dermasel agar, a growth media designed for selection of dermatophyte fungi from hair, nails, and skin scrapings.

      ChromogenicCandida Agar - Candida Selective Supplement

    • Plant Biology Applications

      Because chloroplasts are derived from Cyanobacteria, plants are susceptible to the effects of chloramphenicol. Chloramphenicol can therefore be used as a gene selection agent for resistant plants containing the cat gene.

    • References

      Sharma K.K., Bhatnagar-Mathur P. and Thorpe T.A. Genetic transformation technology: status and problems. In Vitro Cell. Dev. Biol.—Plant 41:102–112, March–April 2005

      Li W., Ruf S. and Bock R., Chloramphenicol acetyltransferase as selectable marker for plastid transformation. Plant Mol Biol (2011) 76:443–451

      Mayer, Gene, Dr. "Antibiotics - Protein Synthesis, Nucleic Acid Synthesis, and Metabolism." University of South Carolina School of Medicine. Web. 21 Aug. 2012.

    Form

    Powder

    Purity Level

    97.0%-103.0%

    Tariff Code

    2941.40.0000

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number56-75-7
    Molecular FormulaC11H12Cl2N2O5
    Molecular Weight323.13 g/mol
    FormPowder
    AppearanceWhite to greyish-white or yellowish-white, needle-like crystals or elongated plate
    Purity Level97.0%-103.0%
    SourceStreptomyces venezuela
    pH4.5 - 7.5
    Melting Point149°C - 153°C
    Optical Rotation+17.0º to +20.0º
    Storage Conditions2-8 °C. Store protected from light