Brefeldin A packaged and labeled.

89.25324.45
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B0125 mg
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B01250 mg
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  • Description

    Brefeldin A is a mammalian and plant cell antibiotic involved in protein transport inhibition and tumor apoptosis.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions. 

    Mechanism of Action

    Brefeldin A inhibits protein transport by preventing accumulation of COPI proteins on the Golgi apparatus which facilitate vesicle fusion from the endoplasmic reticulum (ER). By preventing Golgi-COPI protein function, vesicles from the ER cannot properly fuse with the Golgi to be secreted to destined locations.

    • Cancer Applications

      Brefeldin A has demonstrated anti-cancer properties by inducing apoptosis in leukemia and colon carcinoma cells.

    • References

      Nebenführ, Andreas, et al. "Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion." American Society of Plant Biologists 130.3 (2002): 1102-108. Plantphysiol.org. Nov. 2002. Web. 29 Oct. 2012.

      Shao, R. G. "Brefeldin A Is a Potent Inducer of Apoptosis in Human Cancer Cells Independently of P53." Experimental Cell Research 15.227 (1996): 190-96. Ncbi.gov. Web. 18 Sept. 2012.

    Form

    Powder

    Purity Level

    (HPLC): ≥99.0%

    Tariff Code

    2941.90.1050

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number20350-15-6
    Molecular FormulaC16H24O4
    Molecular Weight280.36
    FormPowder
    AppearanceWhite or almost white powder
    Purity Level(HPLC): ≥99.0%
    SolubilityAcetone: Soluble
    DMSO: Soluble
    Ethanol: Soluble
    Methanol: 10 mg/mL, Clear and colorless or light yellow solution
    Water: Insoluble
    SourcePenicillium brefeldianum
    Storage Conditions2-8°C
  • HPLC Chromatogram Showing Ultra High, Single Fraction Purity of Brefeldin A, EvoPure®

    Brefeldin A HPLC

     

     Mass Spectrometry Results of Brefeldin A

    Brefeldin A Mass Spec