Brefeldin A is a mammalian and plant cell antibiotic involved in protein transport inhibition and tumor apoptosis.
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Mechanism of Action
Brefeldin A inhibits protein transport by preventing accumulation of COPI proteins on the Golgi apparatus which facilitate vesicle fusion from the endoplasmic reticulum (ER). By preventing Golgi-COPI protein function, vesicles from the ER cannot properly fuse with the Golgi to be secreted to destined locations.
Brefeldin A has demonstrated anti-cancer properties by inducing apoptosis in leukemia and colon carcinoma cells.
Nebenführ, Andreas, et al. "Brefeldin A: Deciphering an Enigmatic Inhibitor of Secretion." American Society of Plant Biologists 130.3 (2002): 1102-108. Plantphysiol.org. Nov. 2002. Web. 29 Oct. 2012.
Shao, R. G. "Brefeldin A Is a Potent Inducer of Apoptosis in Human Cancer Cells Independently of P53." Experimental Cell Research 15.227 (1996): 190-96. Ncbi.gov. Web. 18 Sept. 2012.
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