Actinomycin D packaged and labeled.

67.20213.33
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A0015 mg
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  • Description

    Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation by acting as a cytotoxic inducer of apoptosis against tumor cells.

    This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.

    Mechanism of Action

    Actinomycin is a cyclic polypeptide-containing antibiotic that binds to DNA and inhibits RNA polymerase activity. Because Actinomycin can bind DNA duplexes, it can also interfere with DNA replication, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis. Actinomycin D and its fluorescent derivative,7-aminoactinomycin D (7-AAD), are used as stains in microscopy and flow cytometry applications. The affinity of these stains/compounds for GC-rich regions of DNA strands makes them excellent markers for DNA. 7-AAD binds to single stranded DNA; therefore it is a useful tool in determining apoptosis and distinguishing between dead and alive cells.

    • Plant Biology Applications

      Actinomycin D is used in plant tissue culture to inhibit plant growth through tissue deformation. It also acts as an RNA-synthesis inhibitor. Exposure of Actinomycin D at concentrations of 12-20 ug/ml for 3-4 hours in pea and soybean plants caused significant tissue deformation.

    • Cancer Applications

      Actinomycin-D is used to treat Wilms' tumor, rhabdomyosarcoma, germ cell tumors, gestational trophoblastic disease, Ewing's sarcoma, testicular cancer, melanoma, choriocarcinoma, neuroblastoma, retinoblastoma, uterine sarcomas, Kaposi's sarcoma, sarcoma botryoides and soft tissue sarcoma.

    • References

      DJ Morre, 1965. Plant Physiology. Changes in tissue deformability accompanying actinomycin D inhibition of plant growth and ribonucleic acid synthesis.

    Form

    Powder

    Tariff Code

    2941.90.1050

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to [email protected]

  • CAS Number50-76-0
    Molecular FormulaC62H86N12O16
    Molecular Weight1255.42
    FormPowder
    AppearanceRed or orange powder
    Solubility1mg/mL in Acetonitrile - Clear and red or orange solution
    SourceStreptomyces Sp.
    Melting Point243°C - 248°C
    Storage Conditions-20°C
    Assay≥95.0%
    Loss on Drying≤5.0%
    IdentificationPasses test