Vancomycin HCl, USP packaged and labeled.

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  • Description

    Vancomycin HCl, USP is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).

    Vancomycin HCl, USP is freely soluble in water. Click here for more vancomycin products.

    Mechanism of Action

    Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.


    Vancomycin inhibits growth of many Gram positive bacteria including the antibiotic resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus). Vancomcyin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

    • Microbiology Applications

      Vancomycin HCl, USP is commonly used in selective media for isolation of Gram-negative pathogens including Campylobacter jejuni, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, and Neisseria gonorrhoeae.  superbug vancomycin resistant enterococcus (VRE) detection. Representative MIC values include:

      • Methicillin resistant Staphylococcus aureus (MRSA) 0.25 µg/mL - 2 µg/mL
      • Clostridium difficile 0.06 µg/mL - 4 µg/mL
      • For a complete list of vancomycin HCl MIC values, click here.

      Pryjma et al. used TOKU-E vancomycin in Mueller Hinton (MH) medium to isolate Campylobacter jejuni: "FdhTU-Modulated Formate Dehydrogenase Expression and Electron Donor Availability Enhance Recovery of Campylobacter jejuni following Host Cell Infection"


      Media Supplements

      Vancomycin can be used as a selective agent in several types of isolation media:

      Brucella medium - Brucella selective supplement

      Columbia Blood Agar - Campylobacter selective supplement (Skirrow)

      Columbia Blood Agar - Campylobacterselective supplement (Blaser-Wang)

      Wilkins-Chalgren Anaerobe Agar - Isolation of Gram-negative anaerobes

      Legionella CYE Agar - Legionella MWY Selective Supplement

      Columbia Blood Agar - Helicobacter pylori Selective Supplement (Dent)

      Legionella CYE Agar - Legionella GVPC Selective Supplement

      Campylobacter Agar - Campylobacter Selective Supplement (Karmali)

      Bolton Broth - Bolton Broth Selective Supplement

      VRE Medium - VRE Selective Supplement

      mTSB - VCC Selective Supplement

      Campylobacter Agar Base - Modified Karmali Selective Supplement

      Bolton Broth - Modified Bolton Broth Selective Supplement

      Brucella Medium Base - Modified Brucella Selective Supplement

      Legionella CYE Agar - Legionella GVPN Selective Supplement

    • Plant Biology Applications

      Vancomycin is often used in Agrobacterium mediated transformations to control bacterial growth and shows a synergistic effect when used in combination with cefotaxime. Vancomycin does not appear to have any negative effects on plants; however, a study by Silva and Fukai (2001) observed a lower transformation efficiency when >500 µg/ml was used.

    • References

      Courvalin, Patrice. "Vancomycin Resistance in Gram-Positive Cocci." Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.

      Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983

      Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.

      Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369



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    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to

  • CAS Number1404-93-9
    Molecular FormulaC66H75Cl2N9O24 · HCl
    Molecular Weight1485.71
    AppearanceWhite or light brown powder
    Purity Level>80%
    Impurity ProfileVancomycin B: Not less than 85%
    Any Individual Impurity: Not more than 5.0%
    SourceStreptomyces orientalis
    Water Content (Karl Fisher)Not more than 5.0%
    pH2.5 - 4.5
    Storage Conditions2-8°C, protect from light
    Assay(Dried Basis): Not less than 900 μg/mg
    IdentificationIR - Conforms
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