Praziquantel is an anti-helminthic that causes contractions and paralysis in non-resistant organisms. Research suggests praziquantel works mostly by increasing cell permeability.
Praziquantel increases the
permeability of the tegmentum to Ca2+ inducing paralytic
muscle contraction and death. Recent studies have
indicated that praziquantel binds to a variant of the β-
subunit of the voltage gated Ca2+ channel and to actin,
which is a component of some Ca2+ channels.