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Midecamycin

Midecamycin
  • Midecamycin

ModelSizeQtyPrice
M007500 mg
$75.00Add to Cart
M0071 g
$135.00Add to Cart
M00710 g
$1,090.00Add to Cart
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  • Description

    Midecamycin is a macrolide antibiotic similar in structure to erythromycin. Midecamycin is soluble in methanol, ethanol, and acidic solutions.

    Mechanism

    Midecamycin inhibits bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to midecamycin is commonly attributed to mutations in 50S rRNA preventing midecamycin binding allowing the cell to synthesize proteins free of error.

    Spectrum

    Midecamycin is a broad spectrum antibiotic targeting a wide range of bacteria especially those which cause respiratory, ear, and skin infections.

    • Mammalian Biology Applications

      In vitro research of midecamycin showed immunosuppressive properties by inhibiting T-cell responses by suppressing IL-2. These results suggest potential treatment for post-transplant complications and inflammatory diseases.

    Form

    Powder

    Purity Level

    >900 μg/mg

    Related Documents

  • CAS Number35457-80-8
    Molecular FormulaC41H67NO15
    Molecular Weight813.97 g/mol
    FormPowder
    AppearanceWhite powder
    Purity Level>900 μg/mg
    SolubilityBenzene: Soluble
    Chloroform: Soluble
    Ethanol: Soluble
    Ethyl acetate: Soluble
    Ethyl ether: Soluble
    Methanol: Soluble
    Water: Insoluble
    Water (acidic): Soluble
    SourceStreptomyces Mycarofaciens
    Boiling Point874 °C
    Melting Point155 -156 °C
    Flash Point482.4 °C
    Storage Conditions2-8 °C

  • References

    Morikawa, K. "Immunomodulatory Effects of Three Macrolides, Midecamycin Acetate, Josamycin, and Clarithromycin, on Human T-lymphocyte Function in Vitro." Antimicrobial Agents and Chemotherapy 38.11 (1994): 2643-647. Ncbi.gov. Web. 18 Sept. 2012.

    Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.