Midecamycin is a macrolide antibiotic similar in structure to erythromycin. Midecamycin is soluble in methanol, ethanol, and acidic solutions.
Midecamycin inhibits bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to midecamycin is commonly attributed to mutations in 50S rRNA preventing midecamycin binding allowing the cell to synthesize proteins free of error.
Midecamycin is a broad spectrum antibiotic targeting a wide range of bacteria especially those which cause respiratory, ear, and skin infections.
For in vitro research use only. Not suitable for human or animal consumption.
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Lovmar, Martin, and Tanel Tenson. "The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome."Journal of Molecular Microbiology 330.5 (2003): 1005-014.