Vancomycin packaged and labeled.

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  • Description

    Vancomycin is a bactericidal glycopeptide antibiotic and has been used to treat infections caused by multi drug resistant bacteria including methicillin resistant Staphylococcus aureus (MRSA).

    Vancomycin is freely soluble in water. Click here for more vancomycin products.

    Mechanism of Action

    Vancomycin prevents peptidoglycan synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) from linking together forming the peptidoglycan backbone. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain.

    Spectrum

    Vancomycin inhibits growth of many Gram positive bacteria including the antibiotic resistant superbug, MRSA (Methicillin resistant Staphylococcus aureus). Vancomcyin is effective for treating MRSA infections because it inhibits cell wall synthesis through a different mechanism than β-lactam antibiotics.

    • References

      Courvalin, Patrice. "Vancomycin Resistance in Gram-Positive Cocci." Oxford Journals(2006): 25-34. Clinical Infectious Diseaes. Web. 21 Aug. 2012.

      Pollock, H.M., Holt J., and Murray C., Comparison of susceptibilities of anaerobic bacteria to cefemenoxime, ceftriaxone and other antimicrobial compounds, Antimicrob. Agents Chemother., Vol. 23, pp.780-783, 1983

      Silva J.A. and Fukai S., The impact of carbenicillin, cefotaxime and vancomycin on chrysanthemum and tobacco TCL morphogenesis and Agrobacterium growth, J. Appl. Hort., Vol. 3(1), pp. 3-12, 2001.

      Joshi, S., Ray, P., Manchanda, V., Bajaj, J., Chitnis, D. S., Gautam, V., &...Balaji, V. (2013). Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence & susceptibility pattern. Indian Journal Of Medical Research, 137(2), 363-369

    Form

    Powder

    Purity Level

    Vancomycin B: Not less than 93.0%

    Tariff Code

    2941.90.1010

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    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to info@toku-e.com

  • CAS Number1404-90-6
    Molecular FormulaC66H75Cl2N9O24
    Molecular Weight1449.25
    FormPowder
    AppearanceWhite to off-white powder
    Purity LevelVancomycin B: Not less than 93.0%
    Impurity ProfileIndividual Impurity: Not more than 3.0%
    Related Substances: Not more than 7.0%
    Content of EDTA: Not more than 120 ppm
    SourceStreptomyces orientalis
    Water Content (Karl Fisher)Not more than 20.0%
    Absorbance(465nm): Not more than 0.1
    Storage Conditions2-8°C
    Assay(As Is): Not less than 850 µg/mg
    (Dried Basis): Not less than 950 µg/mg
    Residue On IgnitionNot more than 1.0%
    Heavy MetalsNot more than 20 ppm
    IdentificationPasses test