Nybomycin is an unusual heterocyclic metabolite isolated from several Streptomyces species, first reported in 1961 from Streptomyces niveus. Nybomycin possesses antiviral and antibacterial activity. The spectrum of Nybomycin has not been extensively studied. Nybomycins are reported to be 'reverse antibiotics' that inhibit growth of some Gram-positive fluoroquinolone-resistant bacteria by targeting the mutant form of DNA gyrase while being inactive against wild-type strains with fluoroquinolone-sensitive gyrases. In research, the compound can be used to study bacterial DNA replication and repair, and bacterial resistance.
Nybomycin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.