Fumagillin is a polyene natural product and mycotoxin isolated from Aspergillus fumigatus in 1951 as a potent antiprotozoan for agents that cause amoebiasis. More recently, Fumagillin has been shown to inhibit endothelial cell proliferation and angiogenesis in vitro. It is an amebicide and has antibiotic properties and has been used for studying honey bee infections under laboratory conditions. The mycotoxin is produced by enzymes encoded in a biosynthetic cluster located on chromosome 8 of A. fumigatus. Fumagillin is gaining popularity for potential use as a biomarker for invasive aspergillosis.
Fumagillin is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
