Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumor potential of Fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A.
Fostriecin is soluble in water, with optimal stability in aqueous buffered solutions at pH 6.5. NOTE: hydrolysis of the phosphate ester will result from inappropriate storage.
