Amphotericin B, solubilized packaged and labeled in glass bottle.

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  • Description

    Amphotericin B, solublized is a solubilized form of the polyene antifungal or antimycotic, amphotericin B. Amphotericin B is a polyene antifungal or antimycotic compound derived from Streptomyces nodosus.

    Standard powder amphotericin B is nearly insoluble in water and requires the addition of sodium deoxycholate to maximize solubility.

    Mechanism of Action

    Amphotericin B associates with membrane sterols in mammalian and fungal cell membranes. Amphotericin B forms a pore in these membranes leading to essential ion leakage and ultimately, cell death.

    Spectrum

    Amphotericin B is active against mammalian and fungal (molds and yeasts) cells. Amphotericin B is not toxic to bacteria due to their lack of sterols.

    The following represents MIC susceptibility data for amphotericin B against common fungal pathogens:

    • Candida albicans - 0.001 - 321 μg/mL
    • Candida krusei - 0.001 - 16 μg/mL
    • Coccidioides immitis - 0.0625 - 2 μg/mL
    • Cryptococcus neoformans - 0.2 - 39 μg/mL
    • Fusarium oxysporum - 0.75 - 125 μg/mL

    • Microbiology Applications

      Amphotericin B is used as an antimycotic selective agent in several routinely used selective media formulations to inhibit the growth of background fungal growth.

    • Eukaryotic Cell Culture Applications

      Amphotericin B can be used in eukaryotic cell culture to control or prevent fungal contamination. Amphotericin B can be toxic to cell lines at high concentrations and should not be used at concentrations greater than 2.50 µg/mL.

    • References

      Rice, Louis B., and Mahmoud A. Ghannoum. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance." Clinical Microbiology Reviews (1999): 501-17. www.ncbi.gov. Oct. 1999. Web. 22 Aug. 2012.

      Rice L.B. and Ghannoum M.A.. "Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.

      Brajtburg, J., W. G. Powderly, and G. Medoff. "Amphotericin B: Current Understanding of Mechanisms of Action." Antimicrobial Agents and Chemotherapy 34.2 (1990): 183-88. www.ncbi.gov. Web. 22 Aug. 2012.

      Perez-de-Luque A., Cifuentes Z., Beckstead J.A., Sillero J.C., Avila C., Rubio J. and Ryan R.O.. Effect of amphotericin B nanodisks on plant fungal diseases. Volume 68, Issue 1, Article first published online: 24 Jun 2011.

    Form

    Powder

    Tariff Code

    2941.20.5000

    Related Documents


    For in vitro research use only. Not suitable for human or animal consumption. For MSDSs not available online, please email a request to [email protected]

  • CAS Number1397-89-3 (Amphotericin B)
    Molecular FormulaC47H73NO17 (Amphotericin B)
    Molecular Weight924.08 (Amphotericin B)
    FormPowder
    AppearanceYellow or orange powder
    Solubility0.05% in H2O: hazy yellow solution
    SourceStreptomyces nodosus
    Storage Conditions2-8°C
    Assay(As Is): ≥240 µg/mg
    ImpuritiesMycoplasma: None detected
    Endotoxin≤40 EU/mg